Review



recombinant full length murine angptl4  (R&D Systems)


Bioz Verified Symbol R&D Systems is a verified supplier
Bioz Manufacturer Symbol R&D Systems manufactures this product  
  • Logo
  • About
  • News
  • Press Release
  • Team
  • Advisors
  • Partners
  • Contact
  • Bioz Stars
  • Bioz vStars
    • 93
      Buy from Supplier

    Structured Review

    R&D Systems recombinant full length murine angptl4
    FIGURE 5 Lipolysis products induce the expression of <t>Angptl4</t> in MC3T3‐E1 cells. Cells were exposed to 0−150 mg/dL TGRL mixed with 2 units/mL LPL for 3 or 6 h. Bars represent mean ± SEM, n = 4−6, ****p < 0.0001 compared to 0 TGRL + LPL (Ctrl). LPL, lipoprotein lipase; TGRL, triglyceride‐rich lipoproteins.
    Recombinant Full Length Murine Angptl4, supplied by R&D Systems, used in various techniques. Bioz Stars score: 93/100, based on 9 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/recombinant full length murine angptl4/product/R&D Systems
    Average 93 stars, based on 9 article reviews
    recombinant full length murine angptl4 - by Bioz Stars, 2026-02
    93/100 stars

    Images

    1) Product Images from "Lipolysis products from triglyceride-rich lipoproteins induce stress protein ATF3 in osteoblasts."

    Article Title: Lipolysis products from triglyceride-rich lipoproteins induce stress protein ATF3 in osteoblasts.

    Journal: Journal of orthopaedic research : official publication of the Orthopaedic Research Society

    doi: 10.1002/jor.25756

    FIGURE 5 Lipolysis products induce the expression of Angptl4 in MC3T3‐E1 cells. Cells were exposed to 0−150 mg/dL TGRL mixed with 2 units/mL LPL for 3 or 6 h. Bars represent mean ± SEM, n = 4−6, ****p < 0.0001 compared to 0 TGRL + LPL (Ctrl). LPL, lipoprotein lipase; TGRL, triglyceride‐rich lipoproteins.
    Figure Legend Snippet: FIGURE 5 Lipolysis products induce the expression of Angptl4 in MC3T3‐E1 cells. Cells were exposed to 0−150 mg/dL TGRL mixed with 2 units/mL LPL for 3 or 6 h. Bars represent mean ± SEM, n = 4−6, ****p < 0.0001 compared to 0 TGRL + LPL (Ctrl). LPL, lipoprotein lipase; TGRL, triglyceride‐rich lipoproteins.

    Techniques Used: Expressing

    FIGURE 6 Recombinant ANGPTL4 inhibits lipolysis product‐ induction of Atf3 in MC3T3‐E1 cells. Cells were exposed to 100 mg/dL TGRL mixed with 2 units/mL LPL for 6 h. In some experiments, LPL and ANGPTL4 (0.1−5 µg/mL) were mixed for 30 min before the addition of TGRL. Ctrl represents cells not exposed to TGRL/LPL/ANGPTL4. Bars represent mean ± SEM, n = 4−6. *p < 0.05, ***p < 0.001, ****p < 0.0001 compared to 0 µg/mL ANGPTL4. LPL, lipoprotein lipase; TGRL, triglyceride‐rich lipoproteins.
    Figure Legend Snippet: FIGURE 6 Recombinant ANGPTL4 inhibits lipolysis product‐ induction of Atf3 in MC3T3‐E1 cells. Cells were exposed to 100 mg/dL TGRL mixed with 2 units/mL LPL for 6 h. In some experiments, LPL and ANGPTL4 (0.1−5 µg/mL) were mixed for 30 min before the addition of TGRL. Ctrl represents cells not exposed to TGRL/LPL/ANGPTL4. Bars represent mean ± SEM, n = 4−6. *p < 0.05, ***p < 0.001, ****p < 0.0001 compared to 0 µg/mL ANGPTL4. LPL, lipoprotein lipase; TGRL, triglyceride‐rich lipoproteins.

    Techniques Used: Recombinant

    FIGURE 11 (A) Lipoprotein lipase (LPL) (or hepatic lipase) secreted by the osteoblast translocates to the plasma membrane of endothelial cells lining blood vessels, where it catalyzes the conversion of triglyceride‐rich lipoproteins (TGRL) into lipolysis products (LP) such as free fatty acids (FFA). LP translocate to the osteoblast for use as a metabolic fuel source. (B) High circulating levels of TGRL result in high levels of LP which induce an increase in ATF3 in osteoblasts (pathway 1), and induce IL6 and COX‐2, known downstream genes of ATF3; LP also induce intracellular ROS accumulation, which together result in inflammation. LP induce an increase in angiopoietin‐like 4 (ANGPTL4) (pathway 2), an inhibitor of LPL, which may act in a negative feedback loop, reducing LPL activity, reducing LP accumulation in the local environment, and protecting cells from inflammation. Note it is possible that lipases may be active on the osteoblast cell membrane itself. ATF3, activating transcription factor 3; ROS, reactive oxygen species.
    Figure Legend Snippet: FIGURE 11 (A) Lipoprotein lipase (LPL) (or hepatic lipase) secreted by the osteoblast translocates to the plasma membrane of endothelial cells lining blood vessels, where it catalyzes the conversion of triglyceride‐rich lipoproteins (TGRL) into lipolysis products (LP) such as free fatty acids (FFA). LP translocate to the osteoblast for use as a metabolic fuel source. (B) High circulating levels of TGRL result in high levels of LP which induce an increase in ATF3 in osteoblasts (pathway 1), and induce IL6 and COX‐2, known downstream genes of ATF3; LP also induce intracellular ROS accumulation, which together result in inflammation. LP induce an increase in angiopoietin‐like 4 (ANGPTL4) (pathway 2), an inhibitor of LPL, which may act in a negative feedback loop, reducing LPL activity, reducing LP accumulation in the local environment, and protecting cells from inflammation. Note it is possible that lipases may be active on the osteoblast cell membrane itself. ATF3, activating transcription factor 3; ROS, reactive oxygen species.

    Techniques Used: Clinical Proteomics, Membrane, Activity Assay



    Similar Products

    recombinant full length murine angptl4  (R&D Systems)
    93
    R&D Systems recombinant full length murine angptl4
    FIGURE 5 Lipolysis products induce the expression of <t>Angptl4</t> in MC3T3‐E1 cells. Cells were exposed to 0−150 mg/dL TGRL mixed with 2 units/mL LPL for 3 or 6 h. Bars represent mean ± SEM, n = 4−6, ****p < 0.0001 compared to 0 TGRL + LPL (Ctrl). LPL, lipoprotein lipase; TGRL, triglyceride‐rich lipoproteins.
    Recombinant Full Length Murine Angptl4, supplied by R&D Systems, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/recombinant full length murine angptl4/product/R&D Systems
    Average 93 stars, based on 1 article reviews
    recombinant full length murine angptl4 - by Bioz Stars, 2026-02
    93/100 stars
    		  Buy from Supplier

    Image Search Results


    FIGURE 5 Lipolysis products induce the expression of Angptl4 in MC3T3‐E1 cells. Cells were exposed to 0−150 mg/dL TGRL mixed with 2 units/mL LPL for 3 or 6 h. Bars represent mean ± SEM, n = 4−6, ****p < 0.0001 compared to 0 TGRL + LPL (Ctrl). LPL, lipoprotein lipase; TGRL, triglyceride‐rich lipoproteins.

    Journal: Journal of orthopaedic research : official publication of the Orthopaedic Research Society

    Article Title: Lipolysis products from triglyceride-rich lipoproteins induce stress protein ATF3 in osteoblasts.

    doi: 10.1002/jor.25756

    Figure Lengend Snippet: FIGURE 5 Lipolysis products induce the expression of Angptl4 in MC3T3‐E1 cells. Cells were exposed to 0−150 mg/dL TGRL mixed with 2 units/mL LPL for 3 or 6 h. Bars represent mean ± SEM, n = 4−6, ****p < 0.0001 compared to 0 TGRL + LPL (Ctrl). LPL, lipoprotein lipase; TGRL, triglyceride‐rich lipoproteins.

    Article Snippet: Recombinant full length murine ANGPTL4 (4880‐AN‐050) was purchased from R&D Systems.

    Techniques: Expressing

    FIGURE 6 Recombinant ANGPTL4 inhibits lipolysis product‐ induction of Atf3 in MC3T3‐E1 cells. Cells were exposed to 100 mg/dL TGRL mixed with 2 units/mL LPL for 6 h. In some experiments, LPL and ANGPTL4 (0.1−5 µg/mL) were mixed for 30 min before the addition of TGRL. Ctrl represents cells not exposed to TGRL/LPL/ANGPTL4. Bars represent mean ± SEM, n = 4−6. *p < 0.05, ***p < 0.001, ****p < 0.0001 compared to 0 µg/mL ANGPTL4. LPL, lipoprotein lipase; TGRL, triglyceride‐rich lipoproteins.

    Journal: Journal of orthopaedic research : official publication of the Orthopaedic Research Society

    Article Title: Lipolysis products from triglyceride-rich lipoproteins induce stress protein ATF3 in osteoblasts.

    doi: 10.1002/jor.25756

    Figure Lengend Snippet: FIGURE 6 Recombinant ANGPTL4 inhibits lipolysis product‐ induction of Atf3 in MC3T3‐E1 cells. Cells were exposed to 100 mg/dL TGRL mixed with 2 units/mL LPL for 6 h. In some experiments, LPL and ANGPTL4 (0.1−5 µg/mL) were mixed for 30 min before the addition of TGRL. Ctrl represents cells not exposed to TGRL/LPL/ANGPTL4. Bars represent mean ± SEM, n = 4−6. *p < 0.05, ***p < 0.001, ****p < 0.0001 compared to 0 µg/mL ANGPTL4. LPL, lipoprotein lipase; TGRL, triglyceride‐rich lipoproteins.

    Article Snippet: Recombinant full length murine ANGPTL4 (4880‐AN‐050) was purchased from R&D Systems.

    Techniques: Recombinant

    FIGURE 11 (A) Lipoprotein lipase (LPL) (or hepatic lipase) secreted by the osteoblast translocates to the plasma membrane of endothelial cells lining blood vessels, where it catalyzes the conversion of triglyceride‐rich lipoproteins (TGRL) into lipolysis products (LP) such as free fatty acids (FFA). LP translocate to the osteoblast for use as a metabolic fuel source. (B) High circulating levels of TGRL result in high levels of LP which induce an increase in ATF3 in osteoblasts (pathway 1), and induce IL6 and COX‐2, known downstream genes of ATF3; LP also induce intracellular ROS accumulation, which together result in inflammation. LP induce an increase in angiopoietin‐like 4 (ANGPTL4) (pathway 2), an inhibitor of LPL, which may act in a negative feedback loop, reducing LPL activity, reducing LP accumulation in the local environment, and protecting cells from inflammation. Note it is possible that lipases may be active on the osteoblast cell membrane itself. ATF3, activating transcription factor 3; ROS, reactive oxygen species.

    Journal: Journal of orthopaedic research : official publication of the Orthopaedic Research Society

    Article Title: Lipolysis products from triglyceride-rich lipoproteins induce stress protein ATF3 in osteoblasts.

    doi: 10.1002/jor.25756

    Figure Lengend Snippet: FIGURE 11 (A) Lipoprotein lipase (LPL) (or hepatic lipase) secreted by the osteoblast translocates to the plasma membrane of endothelial cells lining blood vessels, where it catalyzes the conversion of triglyceride‐rich lipoproteins (TGRL) into lipolysis products (LP) such as free fatty acids (FFA). LP translocate to the osteoblast for use as a metabolic fuel source. (B) High circulating levels of TGRL result in high levels of LP which induce an increase in ATF3 in osteoblasts (pathway 1), and induce IL6 and COX‐2, known downstream genes of ATF3; LP also induce intracellular ROS accumulation, which together result in inflammation. LP induce an increase in angiopoietin‐like 4 (ANGPTL4) (pathway 2), an inhibitor of LPL, which may act in a negative feedback loop, reducing LPL activity, reducing LP accumulation in the local environment, and protecting cells from inflammation. Note it is possible that lipases may be active on the osteoblast cell membrane itself. ATF3, activating transcription factor 3; ROS, reactive oxygen species.

    Article Snippet: Recombinant full length murine ANGPTL4 (4880‐AN‐050) was purchased from R&D Systems.

    Techniques: Clinical Proteomics, Membrane, Activity Assay